Desmopressin (DDAVP) is a medicine given to people with bleeding disorders to prevent or stop bleeding. This medicine does not work for everyone, so you will need a DDAVP challenge to make sure the medicine will help to clot your blood.
Before Your Visit
For 10 days before your visit: Do not take aspirin or any medicine that contains aspirin.
For 3 days before your visit: Do not take non-steroidal anti-inflammatory medicine (NSAIDS).These include:
Ibuprofen (Motrin® or Advil®)
Read the medicine labels for all other medicines. Medicine used to treat cold and flu, headaches or other pain may contain these medicines.
During Your Visit
You will get a blood test before you get DDAVP.
You will receive DDAVP through a vein or as a nose spray called Stimate®.
You will have another blood test 1-2hours after you received the medicine.
You may need one more blood test4-6 hours later. These blood tests will show if DDAVP works for you.
After Your Visit
DDAVP makes the body hold on to water.
Limit plain water and other fluids for 24 hours after DDAVP.
Drink fluids that have salt in them such as sports drinks, chicken or beef broth and milk.
Liquid Intake Table
Common Side Effects
Temporary facial redness
Mild swelling of arms or legs
Less Common Side Effects
Mild belly cramping
Low blood pressure
Fast heart rate
Seizures due to low blood sodium
When to Call
If you do not urinate (pee) within 12 hours of taking DDAVP
Changes in eyesight
Headache not relieved with acetaminophen (Tylenol®)
Signs of allergic reaction like wheezing or trouble breathing, call 911 right away.
Your healthcare provider will call you with your results within 1 week. If your blood tests show that DDAVP does not work for you, we will tell you about other medicines.
Who to Call
UW Health Comprehensive Program for Bleeding Disorders
(608) 890-9493 or 1-877-737-6707
After hours, contact the pediatric or adult hematologist on call at (608) 262-0486 or 1-800-323-8942.