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This handout will tell you what to do before, during, and after an endometrial biopsy.

About this Procedure

We will take a sample of cells from the lining of your uterus. We will then send the cells to the lab to be looked at under a microscope. 

Before the Procedure

  • You must tell your clinic if you may be pregnant. 

  • You may need to do a urine pregnancy test.

  • You may take 3 ibuprofen tablets (200mg each), or 2 Aleve® tablets (220 mg each), one hour before.

  • Eat a light meal or snack at least one hour before the test (do not arrive fasting).

During the Procedure

It takes only a few minutes.

  • The provider places a speculum into your vagina. 

  • A thin, plastic tube is placed in your uterus through your cervix. This tube takes a small sample of cells. 

  • A small grasping tool may be placed on your cervix to hold it steady. 

  • You may have some cramping. This will decrease once the biopsy is done. 

After the Procedure

You may have some light bleeding, cramping or spotting for up to one week.

When to Call

  • Heavy bleeding (more than a normal period)

  • Severe pain

  • A fever of 100.4° F or higher