This handout will tell you about your endometrial biopsy. It will tell you what to do before during and after the test.

About This Test

A small sample of cells of the lining of your uterus is taken to look for abnormal cells. It can also help decide whether the lining of your uterus can support a pregnancy.

Before the Test

  • You must tell us if there is a chance you are pregnant. You may need to do a urine pregnancy test.

  • You may take 3 ibuprofen tablets (200 mg each) or 2 Aleve® tablets (220 mg each) one hour before.

  • Eat a light meal or snack at least one hour before the test (do not arrive fasting).

During the Test

It takes only a few minutes. The doctor places a speculum into your vagina. The doctor places a thin, plastic tube into your uterus through your cervix. We use this tube to take a small sample of cells. The doctor may place a small grasping tool on your cervix to hold it steady.

You may have some cramping. This will decrease once the biopsy is done. Taking ibuprofen or Aleve® one hour before may help with pain.

After the Test

You may have some light bleeding, cramping, or spotting for up to one week.

When to Call

Call your doctor if:

  • You have heavy bleeding (more than a normal period).

  • You have severe pain.

  • You have a fever 100.4° F or higher.