Irinotecan – 90-minute IV infusion
Leucovorin – 90-120-minute IV infusion (along with Irinotecan) Fluorouracil (5FU) – given 2 ways
1. As a quick (bolus) IV injection given by a nurse through the IV tubing with a 5FU-filled syringe. This will be followed by step 2.
2. A 46-hour IV infusion given by a small pump worn in a fanny pack around the waist. Your chemotherapy nurse will arrange your disconnect at the end of the infusion.
Treatment is given every 14 days.
How to Prepare for Treatment
A PORT is placed for the treatment. This is often done in Interventional Radiology. A nurse will call you before this visit to explain what will happen and answer your questions.
UW Health Care Direct is a home infusion pharmacy that will provide you the 5FU infusion and the pump. A UW Health Care Direct nurse will call you to discuss pump instructions and their service. The 5FU pump will be connected to your port. If your insurance has a contract with a different home health group, UW Health Care Direct will help get this set up.
You will have blood drawn right before the port is placed or within 2 weeks of starting chemo.
We will give you medicine to help treat nausea at your clinic visit before you start the chemo. We will also give you a supply to take home. We may also order you medicine to treat diarrhea.